| Androgen Deprivation Therapy-induced Fractures in Men With ...
Androgen deprivation therapy (ADT), such as orchiectomy or gonadotropin-releasing hormone agonist therapy, is increasingly used for the treatment of localized, high-risk, or biochemical relapse of prostate cancer. Bone mineral density loss is associated with ADT, presenting an increased risk for fractures, and strategies for preventing bone loss include antiresorptive therapy and lifestyle changes, such as smoking cessation and reduced alcohol consumption. Androgen Deprivation Therapy-induced Fractures in Men With Nonmetastatic Prostate Cancer: What Do We Really Know?
Celestia S. Higano, MD
Go to Test Questions .
Dendreon Receives European Patent Covering PROVENGE(R) and Company's ...
SEATTLE, Jan. 15 /PRNewswire-FirstCall/ -- Dendreon Corporation (NASDAQ: DNDN) today announced that the company has been granted a broad European patent covering the company's lead product candidate PROVENGE(R) (sipuleucel-T), the Company's investigational active cellular immunotherapy for the treatment of advanced prostate cancer. European patent No. 0 870 022 B1 covers the composition of matter of PROVENGE as well as the company's other active cellular immunotherapy (ACI) product candidates, such as NEUVENGE(TM) (lapuleucel-T), which utilize Dendreon's Antigen Delivery Cassette(TM) technology. The patent also covers methods of activating antigen presenting cells in vitro with certain fusion proteins developed by Dendreon, including the fusion protein that is used in PROVENGE. "The approval of this broad patent covering PROVENGE and our other active cellular immunotherapies in Europe is an important milestone for the company," stated Mitchell H.
War Blog
That's a good question which, needless to say, Hoyt doesn't try to answer. When I wrote the post linked above, it was obvious how the Times would defend its shoddy journalism. I suggested that the Times undertake a months-long investigation by a team of crack reporters to identify all of the cases in which a newspaper employee has been accused of homicide. I added: No need to wonder whether reporters, editors and typesetters commit homicide at a rate any different from the rest of the population--a single murder is too many! Sure enough, Hoyt writes: A handful of killings caused by the stresses of war would be too many and cause for action. One could say the same about a handful of killings caused by the stresses of the newsroom. In any event, Hoyt admits that the statistical analysis undertaken by his paper's reporters was embarrassingly amateurish.
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