| Androgen Deprivation Therapy-induced Fractures in Men With ...
Androgen deprivation therapy (ADT), such as orchiectomy or gonadotropin-releasing hormone agonist therapy, is increasingly used for the treatment of localized, high-risk, or biochemical relapse of prostate cancer. Bone mineral density loss is associated with ADT, presenting an increased risk for fractures, and strategies for preventing bone loss include antiresorptive therapy and lifestyle changes, such as smoking cessation and reduced alcohol consumption. Androgen Deprivation Therapy-induced Fractures in Men With Nonmetastatic Prostate Cancer: What Do We Really Know?
Celestia S. Higano, MD
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Pharmacopeia Acquires Selective Androgen Receptor Modulator ('SARM ...
PRINCETON, N.J., Oct. 15 /PRNewswire-FirstCall/ -- Pharmacopeia (NASDAQ: PCOP) , an innovator in the discovery and development of novel small molecule therapeutics, today announced that it has licensed from Bristol-Myers Squibb (NYSE: BMY) a selective androgen receptor modulator (SARM) program, including a lead compound in Phase 1 clinical development and back-up compounds. PS178990 is a non-steroidal selective androgen receptor modulator, or SARM, which was designed to provide the benefits of testosterone without its unwanted side effects on prostate. The program has completed a Phase 1 single ascending dose study. SARM agonists are a potential novel treatment for muscle wasting associated with a number of serious chronic and acute medical conditions such as surgical and severe burn recovery, end-stage renal disease and cancer- and AIDS-related cachexia.
Syria arrrests prominent dissident
Syria has arrested prominent dissident Riad Seif as part of an intensifying crackdown on dissent, human rights groups in Damascus reported on Tuesday. Mr Seif, a former MP, was arrested because of his involvement with the “Damascus declaration", calling for democracy in Syria, said Ammar Qorabi, the head of the National Human Rights Organisation. Mr Seif, who suffers from prostate cancer, was denied permission by the authorities to leave the country for medical treatment, a decision he likened to “being sentenced to a slow death." The travel ban was criticised by the US State Department. Syria regularly denies dissidents the right to travel. Mr. Qorabi's statement called Mr Seif who was jailed from 2001 to 2005, a symbol of the Damascus spring. That is a reference to a brief period of more political openness after the current president, Bashar Assad, succeeded his father Hafez Assad in 2000.
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